Blar i forfatter "Brækkan, Sigrid K."

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    • Alcohol consumption, types of alcoholic beverages and risk of Venous Thromboembolism : the Tromsø Study 

      Hansen-Krone, Ida Johanne; Brækkan, Sigrid K.; Enga, Kristin F.; Wilsgaard, Tom; Hansen, John-Bjarne (Master thesis; Mastergradsoppgave, 2011-11-01)
      Moderate alcohol consumption has been shown to protect against cardiovascular diseases. The association between alcohol consumption, especially types of alcoholic beverages, and venous thromboembolism (VTE) is less well described. The aim of this study was to investigate the impact of alcohol consumption and different alcoholic beverages on risk of VTE. Information on alcohol consumption were ...

    • Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort 

      Paulsen, Benedikte; Gran, Olga Vikhammer; Severinsen, Marianne T.; Hammerstrøm, Jens; Kristensen, Søren Risom; Cannegieter, Suzanne C.; Skille, Hanne; Tjønneland, Anne; Rosendaal, Frits; Overvad, Kim; Næss, Inger Anne; Hansen, John-Bjarne; Brækkan, Sigrid K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-21)
      Smoking is a well-established risk factor for cancer, and cancer patients have a high risk of venous thromboembolism (VTE). Conflicting results have been reported on the association between smoking and risk of VTE, and the effect of smoking on VTE-risk in subjects with cancer is scarcely studied. We aimed to investigate the association between smoking and VTE in subjects with and without cancer in ...

    • Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø study 

      Hald, Erin Mathiesen; Løchen, Maja-Lisa; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-06)
      Background Atrial fibrillation (AF) is associated with increased risk of ischemic stroke and all‐cause mortality. Patients with AF are also at increased risk of venous thromboembolism (VTE), but information on how AF impacts VTE‐related mortality is scarce. Objectives - To investigate the impact of AF on all‐cause mortality in subjects with and without a thromboembolic event (VTE or ischemic ...

    • Elevated Plasma Levels of P‐Selectin Glycoprotein Ligand‐1 Positive Microvesicles in Patients with Unprovoked Venous Thromboembolism 

      Jamaly, Simin; Basavaraj, Manjunath Goolyam; Starikova, Irina; Olsen, Randi; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-31)
      Background<br> Microvesicles (MVs) express antigens from their parental cells and have a highly procoagulant surface. Animal studies suggest that P‐Selectin Glycoprotein Ligand‐1 positive (PSGL‐1+) MVs play a role in the pathogenesis of venous thromboembolism (VTE).<p> Objective<br> The aim of this study was to determine plasma levels, the cellular origin and the morphological characteristics ...

    • Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death 

      Arnesen, Carl Arne Løchen; Veres, Katalin; Horváth-Puhó, Erzsébet; Hansen, John-Bjarne; Sørensen, Henrik Toft; Brækkan, Sigrid K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-08)
      Incidence of venous thromboembolism (VTE) risk varies by age and sex. Some studies have reported overall higher risk in men, especially when VTEs triggered by female reproductive factors are excluded. However, higher mortality rates in men may have led to overestimation of lifetime VTE risk in men compared with women. Therefore, we estimated the lifetime risk of VTE in men and women in a Danish, ...

    • Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial 

      Grimnes, Gro; Bhoelan, Soerajja; Hindberg, Kristian; Davids, Mark; Nieuwdorp, Max; Mollnes, Tom E.; Michelsen, Annika Elisabet; Ueland, Thor; Brækkan, Sigrid K.; Hansen, John-Bjarne; Tichelaar, Ynse Ieuwe Gerardus Vladimir (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-24)
      Rationale - Inflammation is present in several conditions associated with risk of venous thromboembolism. The gut microbiome might be a source of systemic inflammation and activation of coagulation, by translocation of lipopolysaccharides from gram-negative bacteria to the systemic circulation.<p> <p>Objective - To investigate whether a vancomycin-induced shift of the gut microbiome in a gram-negative ...

    • Plasma levels of leptin and risk of future incident venous thromboembolism 

      Frischmuth, Tobias; Hindberg, Kristian; Aukrust, Pål; Ueland, Thor; Brækkan, Sigrid K.; Hansen, John-Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-11)
      Background - Circulating levels of leptin, an adipocyte-derived hormone, are frequently elevated in obesity. Leptin has been reported to upregulate prothrombotic hemostatic factors in vitro and could potentially mediate venous thromboembolism (VTE) risk in obesity. However, whether leptin is associated with VTE remains uncertain.<p> <p>Objective - This article investigates the association between ...